The first reported Bigfoot Sasquatch sighting in the area by European settlers occurred in 1886.  One of the most famous sightings occurred near the Klamath River in 1967 in which a few seconds of movie was filmed. 

In fact, the Klamath River  area is ground zero for Bigfoot/Sasquatch sightings.  More sightings have occurred in this area then anyplace else in the world.

(This is frame 352 from the Patterson-Gimlin Bigfoot film...